The importance of the downregulation of miR-200c is further underscored using GSEAs, as they reveal that a large percentage of the previously characterized miR-200c-regulated transcriptome of endometrial and breast cancer cells [32–34] becomes upregulated upon depletion of Vav2 and Vav3 in 4T1 cells (Fig. 3b,c). Here, VAV3 is linked to breast cancer.