To elucidate the potential role of atypical cyclins in CRC, we studied the expression of CCNG1, CCNG2, CCNI, CCNO, CCNY, CNTD1, CNTD2 and SPY1 in four colorectal cancer cell lines, LoVo, HT-29, HT115 and HCA-7, and compared it to the fibroblastic cell line from normal colon CCD-18Co. The gene discussed is CNTD1; the disease is colorectal cancer.