CTSZ and cryohydrocytosis: We measured serum cathepsin Z levels in three clinical stages of PBC (early-stage n = 25, late-stage n = 17, jaundice-stage n = 29), in two clinical stages of CHC (early-stage n = 10, late-stage n = 10), and in obstructive jaundice (n = 12) (Fig. 1).