Integrations into genes specifically associated with HCC (COSMIC database) were only observed in in vitro (CARS, ERBB4 and KDR; 1.9% of integrations in genic regions of the host genome) and HBeAg-positive groups (EGFR, MAP2K7, and TGFBR2; 1.1%), suggesting no significant enrichment with clonal expansion or HBV disease progression. This evidence concerns the gene EGFR and hepatocellular carcinoma.