TRPA1 and lung cancer: Stimulation of A549 cells, a human lung cancer epithelial cell line endogenously expressing TRPA1, with the TRPA1-specific agonist AITC, resulted in the increase of intracellular calcium ([Ca2+]i) and subsequent activation of MAP kinases [86], providing evidence for a functional role of TRPA1 in non-neuronal lung tissue.