Recently, next-generation sequencing studies showed mutations in cancer-driver genes (i.e., AT-rich interaction domain 1A (ARID1A), Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and Kirsten rat sarcoma viral oncogene homolog (KRAS)) in deep infiltrating endometriotic lesions, supporting the idea that the endometriotic microenvironment facilitates mutations [27]. The gene discussed is PIK3CA; the disease is cancer.