To study the effect of HERV-K in the prostatic cancer and its putative links with the SF2/ASF protein, the LNCaP human cell line from a prostate adenocarcinoma was chosen, because transcripts from HERV-K loci occur commonly in prostate cancer cell lines, and both unspliced and spliced HERV-Kenv mRNAs have been described in these cells [7]. The gene discussed is SRSF1; the disease is Familial prostate cancer.