PCBP1 and neoplasm: However, the simultaneous inverse correlation of PCBP1 protein level to that of PRL-3 is observed in only 37% lung and 24% colon carcinoma samples, as PCBP1 silence fails to provoke PRL-3 upregulation in some tumor samples [6], indicating that PCBP1 could play multiple roles in tumor suppression, rather than only by delaying PRL-3 translation.