CDKN1B and cancer: Moreover, GEO data analyses also indicated that simultaneous downregulation of PCBP1 and p27 mRNA is positively related to anticancer drug resistance, including to Tamoxifen, Doxorubincin, and Lapatinib in breast cancer cells (GSE26459, GSE24460, GSE16179) [33–35], respectively (Additional file 13: Figure S11), suggesting the prognostic role of PCBP1 through p27 in cancer therapy.