Nonetheless, the FANCI variant concerns a highly conserved arginine, has previously been described in patients with Fanconi anemia (FA), and has been found to impair DNA binding and ubiquitination of the ID2 complex, a dimeric complex formed by FANCI and FANCD2, which is relevant for DNA crosslink repair [56, 57]. The gene discussed is FANCD2; the disease is Fanconi anemia.