POT1 and brain neoplasm: Associations have been suggested for LFS-associated brain tumors with nonsense PVs in CASP9 (caspase-9) [71], for a POT1 (protection of telomeres 1) missense variant with cardiac and breast angiosarcomas [72], and, as mentioned above, for CDKN2A PVs with hereditary sarcoma cases [17].