Interestingly, clinical presentation of these heterozygous FANCA missense VUS carriers comprises some of the most striking LFL features, involving either very early-onset BC or exceptionally Li-Fraumeni-suggestive personal and family traits, such as a woman with triple primaries (malignant hemangiopericytoma at age 12 years, BC at age 28 years, and contralateral BC at age 47 years) or a woman whose sister and half-brother were diagnosed with two liposarcomas and a melanoma, respectively. Here, FANCA is linked to melanoma.