Intriguingly, more unknown pathogenic variants of ERBB4, FGFR3, ERBB3, and PDGFRA were detected on the catalytic domain of tyrosine kinase, and we also detected unknown pathogenic variants of NOTCH4 on the ankyrin repeat domain in several IBC patients (Fig. 1a). The gene discussed is NOTCH4; the disease is inflammatory breast carcinoma.