We observed a significantly different mutation frequency between IBC and non-IBC patients for the following genes: TP53, CDH1, NOTCH2, MYH9, BRCA2, ERBB4, POLE, FGFR3, ROS1, NOTCH4, LAMA2, EGFR, BRCA1, TP53BP1, ESR1, THBS1, CASP8, and NOTCH1. All genes, except CDH1 which was less frequently mutated in IBC, were more frequently mutated in IBC compared with non-IBC (Fig. 2). This evidence concerns the gene NOTCH4 and inflammatory breast carcinoma.