There were 12 genes with more than 5% mutation frequencies in IBC: TP53, PIK3CA, MYH9, NOTCH2, BRCA2, ERBB4, FGFR3, POLE, LAMA2, ARID1A, NOTCH4, and ROS1. For TP53, PIK3CA, and BRCA2, high mutation rates in IBC have been also reported by other groups. The gene discussed is NOTCH4; the disease is inflammatory breast carcinoma.