FBXW7 and neoplasm: In addition, radiation-induced tumor latency is shorter in FBXW7 heterozygous and PTEN heterozygous knock-out mice (FBXW7+/−; PTEN+/−) compared to FBXW7 heterozygous knock-out mice (FBXW7+/−) and PTEN heterozygous knock-out mice (PTEN+/−) [58].