NOTCH1 and acute lymphoblastic leukemia: However, in T-ALL patients treated in either the Lymphoblastic Acute Leukemia in Adults-94 trials (LALA-94) (n = 87) or the Group for Research on Adult Acute Lymphoblastic Leukemia-2003 trials (GRAALL-2003) (n = 54), Notch1/FBXW7-mutated patients have better overall survival and event-free survival compared with other patients, although there is no correlation between Notch1/FBXW7 mutation and clinical biologic features [111].