First, it did not clarify whether inhibition of Shp2 could modulate other growth factors including basic fibroblast growth factor (FGF), insulin-like growth factor-1 (IGF-1) and epidermal growth factor (EGF) in spite of Shp2 inhibition significantly decreased TGF-β expression in MCT-induced PAH rat lungs. This evidence concerns the gene IGF1 and pulmonary arterial hypertension.