The 3 top canonical pathways were associated with role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis (p-value 1.12E-07), osteoarthritis pathway (p-value 3.63E-07) and differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F (p-value 9.74E-07). This evidence concerns the gene IL17A and rheumatoid arthritis.