The top 3 canonical pathways had genes associated with granulocyte adhesion and diapedesis (CCL2, CCL4, CSF3, CXCL2, CXCR2, CXCR4, FPR1, and IL1R1, p = 1.74E-08), role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis (ADAMTS4, CCL2, CEBPD, FOS, IL6, IL1R1, MYC, OSM, and SOCS3, p = 9.13E-08), and differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F (CCL2, CCL4, CSF3 and IL6, p = 1.15E-07) (Fig. 2c). Here, CCL4 is linked to rheumatoid arthritis.