Other downregulated genes, including breast cancer anti-estrogen resistance protein 1 (BCAR1, also known as p130Cas) and SHC adaptor proteins 3 and 4 (SHC3, SHC4), are key players in the regulation of cell migration by acting as scaffolds for tyrosine kinase-related signaling. The gene discussed is SHC3; the disease is breast carcinoma.