ORMDL3 and asthma: However, the advent of technical and statistical methods for comprehensive GWAS has identified numerous reproducible asthma-susceptibility loci including ORMDL3, IL1RL1, WDR36, PDE4D, DENND1B, RAD50, IL13, IL18R1, SMAD3, HLA-DQB1, GSDMB, IL33, IL2RB, RORA, HLA-DPA1, IL6R, LRRC32, C11orf30, TNIP1 [146, 148–150].