CSF1R and prion disease: While TGFβ signaling and components of CSF1R pathway were increased in ME7 prion mice, a phenotype that has been previously described (Gomez-Nicola et al., 2013, Boche et al., 2006, Cunningham et al., 2002), pro- and anti-inflammatory genes were generally not altered in ME7 mice deficient in PD-1, indicating that PD-1 does not have an significant impact on the inflammatory response in prion disease.