Considering that a greater frequency of cytolytic CD4+CD28- T cells in peripheral blood of MS patients is associated with a worse clinical outcome [44], while a greater frequency of CD4+granzyme B+ cells in SC of mice is associated with a more pronounced tissue damage [94], their higher frequency in the SC of DA rats compared with AO ones correlated with the more severe neuroinflammation in DA animals. This evidence concerns the gene CD4 and myeloid sarcoma.