Considering that a greater frequency of cytolytic CD4+CD28- T cells in peripheral blood of MS patients is associated with a worse clinical outcome [44], while a greater frequency of CD4+granzyme B+ cells in SC of mice is associated with a more pronounced tissue damage [94], their higher frequency in the SC of DA rats compared with AO ones correlated with the more severe neuroinflammation in DA animals. The gene discussed is CD28; the disease is myeloid sarcoma.