TGM4 and lung adenoma: Although Ad-TgP-Cre-mediated BRAFV600E expression was very unlikely even if adenovirus had disseminated systemically, because the Tg promoter we used in this study is exclusively thyroid-specific and has been widely and successfully used for many genetically engineered mice (e.g., Tg-BrafV600E) [2], we found that these nodules were positive for surfactant protein-A (Fig 9), which is reportedly expressed in BRAFV600E-induced lung adenomas [6, 16].