A polymorphism (rs597668) near the EXOC3L2 gene locus has been associated with Alzheimer’s disease (AD) [24], and while no role for EXOC3L2 in AD has yet been proposed it may prove relevant to consider the expression and functionality of alternatively spliced EXOC3L2 isoforms in the context of AD. Here, EXOC3L2 is linked to early-onset autosomal dominant Alzheimer disease.