Over the past 20 years, the NFAT family has been shown to possess important functions, not only in immune cells but also in solid tissues and cells.26, 27 Mounting evidence suggests the NFAT family plays a key role in many types of tumorigenesis.17, 18, 20, 28, 29 In this study, we first determined expression of NFAT family members in HCC and found that NFATc1 mRNA exhibited the biggest difference in expression levels between HCC and corresponding adjacent nontumor tissues. This evidence concerns the gene NFATC1 and hepatocellular carcinoma.