Some studies have demonstrated NFATc1 activation in malignant transformations, such as Burkitt lymphoma, melanoma, pancreatic, colorectal carcinomas, lung cancer, and breast cancer.16, 17, 18, 29, 30, 31 Wang et al32 also found that NFATc1 was overexpressed in HCC and promoted proliferation in HepG2 cell lines. The gene discussed is NFATC1; the disease is melanoma.