APC and pancreatitis: Elevated histone‐degrading activated protein C (APC) levels are associated with better outcomes in sepsis115, 149 and trauma patients137; APC therapy is being evaluated for treatment of sepsis150 and pancreatitis.151 The effects of histones and NETs on the coagulation cascade can be overcome by therapy with thrombomodulin121 or tissue plasminogen activator (tPA),143 but the clot‐stabilizing effects of DNA in NETs must be overcome, which is well illustrated by the finding that DNAse therapy in addition to tPA is more effective than either therapy alone.152