CFTR and cystic fibrosis: In 2013, the Illumina MiSeqDx was the first HTS platform to be approved as an in vitro diagnostic tool by the Food and Drug Administration (FDA), alongside two Illumina diagnostic assays, the CF Clinical Sequencing and CF 139-Variant assays, both of which target the region around the CFTR gene at the genomic level, for screening and diagnosis purposes [79–81].