CPSF6 directly interacts with the viral CA via the same binding pocket as NUP153 (Lee et al., 2010; Matreyek et al., 2013; Price et al., 2012), and when re-localized to the cytoplasm, inhibits HIV-1 infection (Lee et al., 2010). The gene discussed is CPSF6; the disease is HIV-1 infection.