HIV-2 and SIVmac infection were inhibited by many Nup depletions and both were modestly sensitive to depletions of a number of Nups that did not affect HIV-1 infection (e.g. NUP155, TPR, NUP62, NUP54, NUPL1 (Figure 8—figure supplement 4). The gene discussed is NUP58; the disease is HIV-1 infection.