Moreover, some Nup depletions (SEH1, NUP85, NUP160, SEC13, NUP98, NUP107, ELYS/ACHTF1, NUP93, NUP205, NUP88, and NUP214) that reduced both HIV-1 infection and MX2 activity in dividing HeLa cells, affected MX2 activity but not HIV-1 infection in non-dividing HeLa cells. The gene discussed is NUP214; the disease is HIV-1 infection.