The effects of NUP153 depletion on HIV-1 infection in CsA treated cells were also similar to the effects of RANBP2 depletion, rendering HIV-1WT infection CsA dependent (as previously reported (Matreyek and Engelman, 2011; Schaller et al., 2011)) and exaggerating the CsA dependence of HIV-1A94E in HeLa cells. Here, RANBP2 is linked to infection.