CPSF6 and infection: In addition to CA itself, cellular CA-interacting proteins have been suggested to regulate or otherwise influence HIV-1 nuclear import and infection, including the peptidylprolyl isomerase cyclophilin A (CypA) and the mRNA processing protein cleavage and polyadenylation specificity factor 6 (CPSF6) (De Iaco et al., 2013; Lee et al., 2010; Price et al., 2012).