PPIA and infection: The HIV-1G94D and HIV-1A92E CA mutations confer CsA dependence (i.e. their infection is inhibited by CA:CypA binding) during early replication steps in some cell lines, including HeLa, but confer CsA resistance in others, including HOS (Hatziioannou et al., 2005; Sokolskaja et al., 2004) and HT1080 cells (Figure 1 and Figure 1—figure supplements 2 and 3).