CPSF6 and lentivirus infection: The CPSF6 binding interface is also conserved in HIV-2 and SIVmac (Price et al., 2012), and we found that these viruses were particularly sensitive (more so than HIV-1) to TNPO3 depletion (Figure 8—figure supplement 4), further supporting the importance of this interaction for primate lentivirus infection.