ATF6 and achromatopsia: These show that patients harboring ATF6α mutations that render this pathway constitutively active present with the retinal development disorder, achromatopsia, but notably do not show defects in other organs or systemic tissues resulting from constitutive ATF6 activity (Chiang et al., 2017; University of Washington Center for Mendelian Genomics et al., 2015; Kohl et al., 2015).