CYBB and chronic granulomatous disease: In clarifying the role of Nox2 in the antibacterial defense activity of the innate immune defense, a collaboration within clinical medicine, the development of activity assays by biochemists, the discovery of the often short-lived ROS using biophysics methods, the development of in vitro systems derived from neutrophils and macrophages of patients suffering from the different clinical forms of CGD, and the genetic analysis of the families of these patients was necessary for progress to be made in this field.