Hallmark laboratory abnormalities include high LDL, total cholesterol, and triglycerides which are mainly attributed to activation of de novo lipogenesis via SREBP1c as a result of low cytoplasmatic concentration of free cholesterol and fatty acids.2 Low HDL is a consequence of decreased activity of LXR-dependent HDL production.2 Children or adults with LAL-D usually progress to end-stage liver disease with its complications early in life and are at high risk of developing premature atherosclerosis with cerebral or myocardial infarction. Here, SREBF1 is linked to liver disorder.