These were twice combined with additional mutations, including TET2 and SRSF2 mutations in a CMML case, and ASXL1, TET2, and U2AF1 mutations in the disseminated case of an undefined myeloid neoplasm accompanied by HLH (Fig. 3a, b; case 10). This evidence concerns the gene ASXL1 and chronic myelomonocytic leukemia.