PVT1 and cancer: The meta-analysis showed that high expression of PVT1 could predict more lymph node metastasis (LNM) (Odds ratio, OR = 2.83, 95% confidence interval, CI: 1.76–4.54, P < 0.0001), distant metastasis (DM) (OR = 3.60, 95% CI: 1.08–12.03, P = 0.04), advanced clinical stage (OR = 4.37, 95% CI: 3.45–5.54, P < 0.00001) and poor overall survival (Hazard ratio, HR = 2.08, 95% CI: 1.82–2.37, P < 0.00001)in cancer.