C3 and cancer: For example, a set of three complement related genes—complement C3, α-2 macroglobulin and the complement lysis inhibitor SP-40/clusterin (CLU)—that have been implicated in various cancers including gliomas (Reis et al., 2018; Saratsis et al., 2014; Shinoura et al., 1994; Suman et al., 2016) were present in this group, and interestingly, these three proteins have been recently shown to form a network of related biomarkers in B-ALL (Cavalcante et al., 2016).