LEP and polycystic ovary syndrome: Obese PCOS patients needed more dose of gonadotropins, had less mature follicles on hCG day, and less oocytes retrieved after COS.29–31 Altered pharmacokinetics of gonadotropin and high intrafollicular leptin concentration may be related to gonadotropin resistance in obese PCOS women.30 Patients with gonadotropin resistance might have increased the rate of cycle cancellations due to poor ovary responses in common population.