Thus far, a number of FHL1 mutations have been identified, resulting in at least six different X-linked myopathies or cardiomyopathies (Wilhelmsen et al., 1996; Quinzii et al., 2008; Schessl et al., 2008, 2009; Windpassinger et al., 2008; Schoser et al., 2009). Here, FHL1 is linked to cardiomyopathy.