Figure 1A shows that sPLA2 activity was increased by appreciatively twofold in C1-INH-HAE patients in symptom-free period compared with controls [sPLA2: 2.4 (1.3–3.0) vs 1.3 (0.6–1.8) U/ml median values (interquartile ranges)]. The gene discussed is SERPING1; the disease is hereditary angioedema.