ITGAM and neoplasm: However, a significant increase in CD11b+Gr-1− cells was exclusively observed in the tumor tissues and spleens of tumor-bearing mice when compared with the same in normal controls (45.13 ± 0.85 vs. 7.20 ± 0.30 vs. 4.17 ± 0.30%, P < 0.0001, P = 0.0019) (Figure 3A).