CD11b+Gr-1− e-MDSCs were also isolated from the spleens of 4T1WT (sMDSCWT), 4T1NC (sMDSCNC), and 4T1IL-6low (sMDSCIL-6low) tumor-bearing mice and cocultured with normal spleen T cells to individually investigate proliferation, apoptosis, and cytokine production. The gene discussed is ITGAM; the disease is neoplasm.