Simultaneously, significant decrease in the number of CD11b+Gr-1− e-MDSCs in primary tumor tissues was also observed in IL-6R Ab- and JSI-124-treated mice when compared with untreated controls (22.73 ± 2.39 vs. 21.70 ± 1.55 vs. 46.70 ± 3.70%, P = 0.0055, P = 0.0034, Figure 7C). This evidence concerns the gene ITGAM and neoplasm.