Other NDs also display deregulated miRNA biogenesis (Tan et al., 2015); upregulation of Drosha, DGCR8 and Dicer has been observed in MS patients brain (Jafari et al., 2015); further, abnormal cellular distribution of Drosha (Porta et al., 2015) and Dicer dysfunction (Emde et al., 2015) have been reported in ALS patients brains. Here, DROSHA is linked to amyotrophic lateral sclerosis.