Other NDs also display deregulated miRNA biogenesis (Tan et al., 2015); upregulation of Drosha, DGCR8 and Dicer has been observed in MS patients brain (Jafari et al., 2015); further, abnormal cellular distribution of Drosha (Porta et al., 2015) and Dicer dysfunction (Emde et al., 2015) have been reported in ALS patients brains. The gene discussed is DICER1; the disease is myeloid sarcoma.