Although AurA mediates GBM radio-resistance in the absence of exogenous CXCL12 stimulation, it is important to keep in mind that GBM cells themselves secrete CXCL12 to trigger CXCL12–CXCR4 autocrine/paracrine signaling [39, 40]. Here, CXCL12 is linked to glioblastoma.