HIF-2α has oncogenic function in ccRCC and promotes c-Myc, a vital oncogenic stem cell factor activity in pVHL −/− ccRCC, inhibits p53 activity, and decreases subsequent p53-induced apoptosis upon γ-radiation, resulting in radio resistance, a significant feature of CSCs37. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.