In RCC, the respective nuclear and cytoplasmic expressions rate for OCT4 were 100% (186/186) and 95.2% (177/186), respectively, while the respective cytoplasmic and nuclear expressions rate for NANOG were 97.3% (181/186) and 82.8% (154/186), with varying levels of intensities. This evidence concerns the gene POU5F1 and renal cell carcinoma.