One gene (CXCL13) was found upregulated in Tumor versus Normal, TLS positive versus Normal and Normal TLS positive, another gene (ICA1) was upregulated in Tumor versus Normal, TLS negative versus Normal and Normal TLS positive, and one more gene (CD52) was upregulated in TLS negative versus Normal and Normal TLS positive (Fig. 4b and Supplementary Table S10). This evidence concerns the gene ICA1 and neoplasm.