There was an overexpression of several genes involved in negative regulation of apoptosis (Wisp2, Fmod, Nceh1, Cygb, and Nnt)12–16, tumor suppression (Nr4a1, Sox15, and Msap1)17,18, oxidative-stress response (Atp10d, Cxcl11, Nnt, and Cygb)12,16,19, tissue remodeling (Mmp12)20, and cell survival (Tlr6, Nr1d1, Tpsb2, IL-22r1, Nr4a1, Prox1, and Fam198a)21–23 in UVB-exposed Cbl-b−/− compared to WT mice. The gene discussed is TPSB2; the disease is neoplasm.