To identify genes that are directly regulated by HLX in human hematopoietic cells, we performed ChIP-Seq in two mammalian cell lines (chronic myelogenous leukemia CML: K562 and acute myeloid leukemia-AML HL60) overexpressing a FLAG-tagged version of hHLX (Supplementary Fig. 5a). Here, HLX is linked to acute myeloid leukemia.