APOE and familial hypercholesterolemia: Plasma cholesterol levels in WT mice transplanted with apoE KO BM were similar to those of apoE KO mice transplanted with WT BM, as was cholesterol distribution in the different lipoprotein subclasses (VLDL, LDL and HDL) (Fig. 2c, d and Supplementary Figure 4A), ruling out the possibility that faster rejection was simply the consequence of hypercholesterolemia.