Metastasis-associated in colon cancer 1 (MACC1), originally identified as a critical regulator of the HGF-MET signaling, is frequently overexpressed in CRC and promotes proliferation, epithelial-mesenchymal transition (EMT), metastasis, CSC-like properties, and chemoresistance of colon cancer cells by acting as a transcriptional activator of c-MET and other cancer-related genes including SPON2, OCT4, NANOG, and MDR1/ABCB115–19. Here, SPON2 is linked to cancer.