Cox analysis using the GSE28722 and GSE24551 datasets showed that mRNA levels of MACC1 and DBC1 are significantly upregulated in high-risk groups of CRC patients, and that high expression of MACC1 and DBC1 is associated with poor overall and disease-free survival (Fig. 6f, g and Supplementary Fig. S7). Here, CCAR2 is linked to colorectal carcinoma.