PROX1 and colorectal carcinoma: In addition, DBC1 not only promotes the expression of a Wnt/β-catenin-inducible transcription factor PROX1, which plays a critical role in CRC progression, but also serves as a coactivator of PROX1, suggesting DBC1 as a key regulator in CRC progression driven by Wnt/β-catenin-PROX1 signaling9.