Importantly, gene expression deconvolution of TCGA RNA-Sequencing also revealed a relationship between high Trps1 activity and low frequency of intra-tumoural immune cells (Fig. 8g) since tumours demonstrating high Trps1 activity showed a strongly reduced frequency of CD4, CD8 and natural killer (NK) cells, respectively (Fig. 8g). Here, CD8A is linked to neoplasm.