TRPS1 and breast carcinoma: To gain more mechanistic insights into TRPS1’s repressive effect on YAP/TEAD target gene expression in breast cancer cells, we performed ChIP-Sequencing for TRPS1 in MCF7 and T47D cells, since genome-wide binding profiles for this factor had not been reported previously (Fig. 3a, b; Supplementary Fig. 3a, b).