TRPS1 and breast cancer: Hereby, we have identified the transcriptional repressor protein Trichorhinophalangeal Syndrome 1 (TRPS1) as a new repressor of YAP/TEAD-dependent transcription in breast cancer cells by specifically recruiting corepressor complexes to YAP/TEAD sites, altering the chromatin structure and changing enhancer–promoter interactions of YAP target genes.