Some of the traits were chosen because they are phenotypically related to SZ (e.g. neuroticism, depressive symptoms, major depressive disorder, autism and childhood IQ), while others were less obviously related to SZ (e.g. age at menarche, intracranial volume and cigarettes per day) or served as negative controls (height, birth weight, birth length and fasting (pro)insulin). The gene discussed is INS; the disease is major depressive disorder.