MAPT and Alzheimer disease: Forebrain-specific loss of O-GlcNAcylation results in progressive neurodegeneration, including widespread neuronal cell death, neuro inflammation, increased production of hyper phosphorylated tau and amyloid genic Aβ-peptides, and memory deficits in adult mice [100], indicating the involvement of O-GlcNAcylation in the progression of AD.