Inhibitory effects of MA or HCD on breast cancer cell lines, specifically the ERα-negative MDA-MB-231 and ERα-positive MCF-7 and the molecular targets and signaling pathways include anti-apoptotic genes-Bcl-2, pro-apoptotic-Bax, and tumor suppressors (such as p53), were investigated. This evidence concerns the gene BCL2 and breast carcinoma.