Besides NF2, 4 genes, SMO, TRAF7, AKT, and KLF4 have been identified from a series of whole genome and exome sequencing efforts conducted on clinical meningioma specimens; these mutations are present in 40% of sporadic meningiomas and are mutually exclusive with chromosome 22 mutations including NF2 [5,21,22]. This evidence concerns the gene KLF4 and meningioma.