CDKN2A and cancer: High-throughput DNA-methylation profiling techniques uncovered that global hypomethylation is accompanied by increased promoter methylation of genes that are established tumor suppressors (such as BRCA1 [26,27], p16/INK4a [28], RASSF1A [29], and MLH1 [30]) and results in their silencing in different cancer types [31,32,33,34].