IAPP and type 2 diabetes mellitus: Furthermore, a recent study reported that amylin aggregates administered by intraperitoneal (i.p.)injection to human amylin-expressing transgenic mice induce human amylin aggregation by seeding endogenous human amylin in pancreatic islet β-cells and increase blood glucose concentration, implying that T2D may be transmissible via amylin aggregates that act like prions [99].