Odds ratios for disease in subjects heterozygous (GT) and homozygous (TT) for the minor allele of this MUC5B polymorphism (rs35705950) have been quoted as 6.8 (95% confidence interval (CI), 3.9–12.0) and 20.8 (95% CI, 3.8–113.7) for familial cases, and 9.0 (95% CI, 6.2–13.1) and 21.8 (95% CI, 5.1–93.5) for IPF [48], with validation in several independent cohorts [49,50], although the minor allele is present in 19% of non-Hispanic white populations, many without disease [51]. The gene discussed is MUC5B; the disease is idiopathic interstitial pneumonia.