Treating cultured human breast cancer cells with an NO donor (Box 1) resulted in the activation of the epidermal growth factor receptor (EGFR) and of the extracellular signal-regulated kinase (ERK) pathways through EGFR S-nitrosylation, with a subsequent increase in the migration and invasive potential of these cells (Garrido et al., 2017). The gene discussed is EGFR; the disease is breast cancer.